The reason for the weakness of hypermobile EDS bones may be limited activity Exercise is preferred to reduce the risk of broken bones

Poor bone density and mineral content can be common in affected people Hyperactive Ehlers-Danlos Syndrome (hEDS), most likely as a result of decreased physical activity, a study suggests.

“Based on the results of this study, we suggest that healthcare workers, as in healthy individuals, recommend regular physical activity and muscle strength training in individuals with hEDS and G-HSD. [generalized joint hypermobility spectrum disorder] for bone maintenance,” the researchers wrote.

the study, “Bone parameters in hyperactive Ehlers-Danlos syndrome and hyperactive movement spectrum disorder: a comparative cross-sectional study,” in the magazine bone.

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The key to bone health is to determine the risk of bone fractures

hEDS and generalized hyperactivity spectrum disorder (G-HSD) are both characterized by Symptoms of the disease Unusually mobile joints, chronic pain, and fatigue. People with either condition usually find it difficult to exercise and muscle strength can be diminished.

While this can affect bone health, little research has been done on adults with hEDS or G-HSD. A team of scientists at the University of Ghent in Belgium set out to find out more.

“Because individuals with hEDS and G-HSD have impaired gait, decreased coordination and balance, and a higher incidence of falls, insight into the bone properties of this population is of great importance for estimating their fracture risk,” the authors write.

The study included 20 women with hEDS, 20 with G-HSD, and 37 women without any condition as a control group. Their average age ranged from 40.8 to 43.8. Subjects with hEDS or G-HSD scored significantly lower on measures of physical activity than controls, but no differences in medical history were observed across the three groups.

A technique called dual-energy X-ray absorptiometry, or DXA, was used to measure bone density and mineral content, as well as muscle and fat mass, in all of these people.

“This study was the first to evaluate bone mass, density, geometry, and bone strength estimates in individuals with hEDS and G-HSD diagnosed according to the most recent 2017 standardsScholars wrote.

Significantly less muscle mass was evident in subjects with hEDS or G-HSD relative to controls. There were no statistically significant differences between the two groups of patients.

Patients in both groups also had significantly lower bone mineral content in the cortical bone area (the dense outer layer of bone) than in controls, and the mean cortical bone area was significantly smaller in individuals with hEDS or G-HSD.

The hEDS patients also had reduced bone mineral content in trabecular bone, a type of spongy bone tissue, and significantly lower bone density compared to the control group.

While these differences were statistically significant in the initial comparisons, when the researchers made statistical adjustments to account for differences in physical activity, most measures were no longer significantly different.

This indicates that the difference in bone health is mainly due to a lack of mechanical load, the scientists noted. In other words, because people with hEDS or G-HSD tend to be less active, their bones do less work to support their bodies, which leads to less activation of biological pathways that normally help keep bones healthy.

This study showed that there were no different bone profiles between individuals with hEDS and G-HSD, indicating their bone weakness may not be reflected in the different diagnostic classification,” the researchers wrote. “RThe results indicate low cortical bone minerals Content and smaller scales in individuals with hEDS and G-HSD, and Lower trabecular bone mass and density in individuals with hEDS “relative to the control group,” which It can be largely explained by lower mechanical loading.”

The researchers concluded that the findings indicate that regular physical exercise can help improve bone health for people with hEDS or G-HSD.

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