New herbicide solution inspired by cholesterol drugs

محلول مبيد أعشاب جديد مستوحى من أدوية الكوليسترول

The herbicide activity of statins varies between the Dicot and Monocot model. Representative images from post-treatment of cotyledons, A. thaliana, and pre-treatment of monocot-emergent E. tef, with statins: rosuvastatin (Ro.), pravastatin (Pr.), simvastatin (Si.), mevastatin (Me.), lovastatin (Lo.), fluvastatin (Florida), atorvastatin (At.) and pitavastatin (Pi.). A. thaliana (green) and E. tef (grey) were treated with a set of statins at 62.5 μM before (light color) and after (dark color) on the soil. Inhibition was quantified using the green pixel area and plotted as a percentage control for the absence of inhibitor. n = 3 replicates with mean ± standard deviation (s.d.). The source data is provided as a source data file. attributed to him: Nature Communications (2022). DOI: 10.1038 / s41467-022-33185-0

Curtin University researchers have discovered a promising new site for targeting herbicides in plants with the potential to provide new solutions for farmers dealing with the growing problem of herbicide resistance.

Recently Posted in Nature Communications Led by researchers from the Curtin Center for Crop and Disease Management (CCDM) in collaboration with the University of Western Australia, the research used statinsA class of chemicals commonly used in humans to lower cholesterol enzyme In plants that could be a target site for the development of a new group of herbicides.

CCDM lead author and researcher Dr. Joel Haywood said that after researching a group of more than 1,500 existing and well-understood drugs, his team stumbled upon statins, and decided to explore their herbicide properties further.

statins were first found in fungi During the mid-1970s, fungi used them to defend themselves from other microorganisms.”

“Statins will bind to an enzyme called HMGR, and when applied to the plantsThis will stop the enzyme from producing important fats, hormones, and vitamins, causing the plant to die. We also found a statin-tolerance trait from fungi that produce statins. They have a second HMGR enzyme that statins don’t affect, to make sure the fungi don’t kill themselves with their statins.

“As part of this research, we identified the first 3D form of the plant HGMR enzyme, allowing us to discover differences that we can exploit to make statins more specific to plants.

“With this 3D model, the team will now be able to focus on finding the best chemicals that can block the enzyme by searching through virtual chemical libraries.”

Co-author and Deputy Director of CCDM Professor Josh Milne said that while statins are unlikely to be used in herbicides given their vital importance as human medicines, this research paves the way for new types of chemicals that can inhibit HMGR and thus kill weeds.

Like it or not, herbicides are essential to modern large-scale farming, but the overuse of major herbicides has encouraged herbicides“Weeds are resistant to multiply,” Professor Mellin said.

“Over the past 40 years, only one new herbicide group has reached the market, which means that finding new herbicide options for farmers is more important than ever, if we are to avoid further pressure on the food security.

“This research will give agricultural industry Some hope that new ideas are in the pipeline to manage weeds, help farmers reduce yield losses and allow for improved productivity.

“The work we’ve done so far will make this happen faster, so watch this space.”


A new approach to preserving crops, people’s safety


more information:
Joel Haywood et al, Fungi-tolerant trait and selective inhibitor offering HMG-CoA reductase as a herbicide, Nature Communications (2022). DOI: 10.1038 / s41467-022-33185-0

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the quote: New Herb Solution Inspired by Cholesterol Medicine (2022, Sep 27) Retrieved on Sep 27, 2022 from https://phys.org/news/2022-09-herbicide-solution-cholesterol-medicine.html

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