A call to turn mental health genetic discoveries into better treatments for patients

دعوة لتحويل الاكتشافات الجينية للصحة العقلية إلى علاجات أفضل للمرضى

The main challenges in the field of psychological genetics. attributed to him: natural genetics (2022). DOI: 10.1038 / s41588-022-01174-0

QIMR Berghofer scientists are challenging the research and funding community to develop better treatments for debilitating mental health conditions by taking advantage of the many extraordinary genetic discoveries made over the past decade to advance a new era of precision psychiatry.

Scientists have discovered hundreds, and in some cases, thousands of genes linked to a whole range of mental health conditions, including anxiety, depression, anorexia nervosa, and schizophrenia. Two-way disorderAutism spectrum disorder and attention deficit hyperactivity disorder. This is made possible by new sets of DNA genetic data donated by millions of people, and advances in supercomputing technology.

Now is the time to take this research to the next stage, said the head of QIMR Berghofer’s Translational Neurogenetics Laboratory, Professor Eske Dirks.

I co-led a new study published in natural geneticsIdentifying 10 major challenges that must be overcome before these genetic discoveries will lead to improved patient care in the clinic.

“We have gone through an era of genetic discovery, and we are now on the cusp of a new era of precision psychiatry that can deliver more effective medicines to patients, and can help clinicians better diagnose and treat these complex conditions.

“The challenges we have identified are not easy to solve but through a creative, collaborative and coordinated research approach, and the investment that supports scientists to do this work, we can make this new era a reality. We owe it to the people who have generously donated their DNA and to those who live with a mental illnessProfessor Dirks said.

Two in five Australians will suffer from mental illness at some point in their lives. Anxiety and depression are the most common, with the COVID-19 pandemic causing a 25% increase in cases according to the World Health Organization (WHO). Mental illness can significantly affect patients’ quality of life, costing the Australian economy about $70 billion each year.

Dr Zachary Gering, who co-led the study, said there is a huge opportunity to use genetic data to find more effective treatments.

“For decades, there has been little progress in development new drugs for mental health conditions. It can be a long process of trial and error for patients to find a cure.

We can merge genetic data With drug databases to identify potential new drug candidates that can be redirected for treatment mental health conditions. Reusing approved drugs for specific purposes means we can get them to patients more quickly and at a lower cost than developing an entirely new drug,” Dr. Gering said.

QIMR Berghofer Ph.D. Candidate and co-lead author, Jackson Thorpe, said there is huge potential for using genetic discoveries to unlock the biological mechanisms of psychological diseases.

“Our studies show that there is a significant genetic component that points to an underlying biological basis,” said Mr. Thorpe. “Mental health conditions are diseases that have a biological basis, just like other diseases such as diabetes.”

Through a better understanding of biological processesWe can find causes of mental health conditions that can lead to identification of high-risk groups of people, more tailored interventions, and more accurate diagnostic tools.

“I am very optimistic that we can use this genetic information To improve the lives of people with mental illness, but we really need funding to do this work,” said Mr. Thorpe.

We found a genetic link between routine blood test results and mental health disorders

more information:
Eske M. Derks et al., Ten Challenges to Clinical Translation in Psychogenetics, natural genetics (2022). DOI: 10.1038 / s41588-022-01174-0

Provided by QIMR Berghofer Institute for Medical Research

the quote: A call to turn mental health genetic discoveries into better treatments for patients (2022, Sep 27) Retrieved on Sep 27, 2022 from https://medicalxpress.com/news/2022-09-mental-health-genetic-discoveries-treatments.html

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